I can't think of a single game were we used the poisons in the book. The GM always made his own poisons and most still had minor effects even if you saved which I think is more real. You can add a duration to the poisons and turn the damage into damage per round for the duration, or untill a neutralize poison is used. Also if a character dies by poison then a neutralize poison must be used befor a resurection or the character starts taking the poison damage all over again. One of the deadlyest poisons I've made was half life basicly the character had to make a 250 save if they fail they half every thing hits, power points, skills, DB, OB, and even saves, this initial damage can not be healed untill a neutralize poison is cast, then they take one aditional hit per minute untill they die or neutralize poison is used these additional hits can be restored by magic but it won't stop further damage. If the character failed by more than 100 or fumbled they are dead, if they saved they still took one hit a minute untill neutralize poison was cast. Obviously this poison is to be used on higher level characters so they can have a fighting chance.