I played a RM Planescape short campaign, once.
We basically dumped all the spells levels and item bonuses shifting, because:
a) the book keeping it took was just too much for our tastes
b) it felt somehow artificial/out of place. I don't know, the whole setting is based around planar exploration, but for some reason it "punishes" for visiting other planes. Never understood why.
c) it penalized priests and other "divine" characters more than any other class, thus discouraging people from playing them. Which is also strange, IMO, for a setting where gods and belief played such a huge role.
What we did was giving each plane/realm special rules for magic. Like, in the Lower Planes you got free access to "Evil" lists (or maybe some of your lists were temporarly "swapped" with their Evil counterpart), but were susceptible to corruption.
For for Lawful planes we used the spell use risk chart, meaning that casting powerful spells would get you the attention of some powerful planar being nearby.
Things like that, much time has passed, so my memory is a bit fuzzy