interesting ideas! It sounds like this concept might suit a post-apocalyptic setting like Gamma World. You could draw inspiration from any number of films, a few of them horror themed. radiation and mutations would add some cool elements to your setting. Old school films like Mad Max offer a gritty, barren landscape filled with marauders and sparse supply of resources and weaponry. Add in some AI elements such as from Terminator or the more recent film The Creator and things could get pretty interesting no matter what game system u were using.