Space adaption would be tolerance to freefall conditions: Bones don't leach calcium, muscles don't atrophy, tissue drainage isn't effected, immune cell circulation/surveillence isn't comprimised. Freefall sickness/ the need for a visual horizon is banished.
vaccuum adaption: Tolerance to a lack of pressure (perhaps internally strengthend cell/organ membranes. It would imply a tolerence to cold as well. Also some form of contained breathing, so your lungs/gills/gas transport system doesn't rupture.