I think a Frankenstein-ilke profession could be an idea. In RMCVII it was called "Creator", I think. Stitching together flesh golems or weird undead from different body parts might be an idea. I also like the idea of grafts (if that is the correct term) from Dark Space, monster, demonic or even undead part "grafted" (am I using this correctly) into the targets/victims body giving him powers but also making him ... well weird, strange, dangerous, maybe a powerful ally but also a ticking time bomb that then becomes a horrible enemy. I like the idea of having things that have a benefit but also a risk of going horribly wrong, especially if this is something you could then use in your campaign to create interesting situation and twists.
I also always like the Chaotic Lord sort of, good idea.
And then there are these physical alteration options and crits from the old Warlock (I think) those were pretty cool for NPCs ... never saw a PC of that profession.
Talking about wyrd, there should definitely be some sort of profession that is self-taught, a bit like the old Chaotic from RMSS Arcane Companion maybe, but with lots of spell flexibility, maybe not a set sphere but the ability to see, study and then learn spells he has encountered. With more difficult spell casting manoeuvres or some other drawback,
That profession wouldn't be necessarily evil but he would definitely be more Wyld or Wyrd than other ... and therefore might be considered evil in the sense of chaotic and dangerous to the system by spell-users of more organiserd traditions. To be honest, I have no idea how to put such an ability into gaming rules or mechanics ... but then I am not an author of rulebooks.