I voted maybe, and even then I would use it only as a reference.
I have a few reasons why I wouldn't use a 'direct from box' setting, but the main one being my own arrogance. I vehemently believe I could do better, at least from mine and my players point of view.
We use a lot of house rules, defined power levels, battered 2E books and a quarter of a century RM experience and stories to draw from.
Also, for me at least, a large part of GM craft and the enjoyment of running games, comes from the creative process, whether that be creating the game world, setting or modified rule-set, or manufacturing adventures, NPCs or items.
So, where does the 'maybe' come in? Ideas. Not s much for a setting, but just ideas of how others have created their worlds and how they have pulled everything together.
However, as a disclaimer, there may be times when a 'direct from box' setting could be useful, especially for new gamers or those pressed for time.