Markc,
I have yet to run a SM2 campaign but hope to do so in the future. My campaign will likely include bio-engineering as an important aspect of some of my societies. Some will have it cloaked in ritual & secrecy, while others will be open about it. The Imperium seems to be open to it with their Transhuman "races". I'll likely use the default setting with some tweaks & additions; I've been reading some Traveller books & supplements - they have some interesting bits I might steal & tweak for SM2. That said, I'll not likely run it, but I'll play in it. I'll only run ICE games & Lamentations of the Flame Princess.