Hey there,
I loved Talislanta in theory, but found it a bit difficult in practice. Like Forgotten Realms, it was very hard to have a free form game without someone saying 'Oh, you can't place your adventure there, that's where the Black Seers are'.
Talislanta sure had A LOT of cultures, but I thought it was great, all-in-all.
-Uriel
PS: The picture of The Vasp was the single most creepy as f&%k picture in the history of gaming (Shudder).